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Tooth development begins at week 6 in utero, in the oral epithelium. The process is divided into three stages: Initiation; Morphogenesis and; Histogenesis [2]; At the end of week 7 i.u., localised proliferations of cells in the dental laminae form round and oval swellings known as tooth buds, which will eventually develop into mesenchymal cells and surround the enamel organ.
The tooth bud (sometimes called the tooth germ) is an aggregation of cells that eventually forms a tooth and is organized into three parts: the enamel organ, the dental papilla and the dental follicle. [3] The enamel organ is composed of the outer enamel epithelium, inner enamel epithelium, stellate reticulum and stratum intermedium. [3]
The bell stage is the fourth stage of tooth development which occurs between the eleventh and twelfth week of prenatal development.During this stage of odontogenesis, the epithelial tooth germ forms a bell-shaped structure in the labio-lingual section and is characterised by the formation of the dental sac.
Enamel lamellae are a type of hypomineralized structure in teeth that extend either from the dentinoenamel junction (DEJ) to the surface of the enamel, or vice versa. In essence, they are prominent linear enamel defects, but are of no clinical consequence. [1] These structures contain proteins, proteoglycans, and lipids.
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Enamel tufts are hypomineralized ribbon-like structures that run longitudinally to the tooth axis and extend from the dentinoenamel junction (DEJ) one fifth to a third into the enamel. [1] They are called tufts due to their wavy look within the enamel microstructure.