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An example of a Kaplan–Meier plot for two conditions associated with patient survival. The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data.
Survival analysis is a branch of statistics for analyzing the ... 19 27 1 Nonmaintained 6 28 ... Kaplan–Meier curves and log-rank tests are most useful when the ...
Survival analysis includes Cox regression (Proportional hazards model) and Kaplan–Meier survival analysis. Procedures for method evaluation and method comparison include ROC curve analysis, [ 6 ] Bland–Altman plot , [ 7 ] as well as Deming and Passing–Bablok regression .
The curve represents the odds of an endpoint having occurred at each point in time (the hazard). The hazard ratio is simply the relationship between the instantaneous hazards in the two groups and represents, in a single number, the magnitude of distance between the Kaplan–Meier plots. [11] Hazard ratios do not reflect a time unit of the study.
The logrank test is based on the same assumptions as the Kaplan-Meier survival curve—namely, that censoring is unrelated to prognosis, the survival probabilities are the same for subjects recruited early and late in the study, and the events happened at the times specified. Deviations from these assumptions matter most if they are satisfied ...
Within the analysis module, analytic routines include t-tests, ANOVA, nonparametric statistics, cross tabulations and stratification with estimates of odds ratios, risk ratios, and risk differences, logistic regression (conditional and unconditional), survival analysis (Kaplan Meier and Cox proportional hazard), and analysis of complex survey ...
Paul Meier (July 24, 1924 – August 7, 2011) [1] was a statistician who promoted the use of randomized trials in medicine. [2] [3]Meier is known for introducing, with Edward L. Kaplan, the Kaplan–Meier estimator, [4] [5] a method for measuring how many patients survive a medical treatment from one duration to another, taking into account that the sampled population changes over time.
An early paper to use the Kaplan–Meier estimator for estimating censored costs was Quesenberry et al. (1989), [3] however this approach was found to be invalid by Lin et al. [4] unless all patients accumulated costs with a common deterministic rate function over time, they proposed an alternative estimation technique known as the Lin ...