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Early treatment of an ectopic pregnancy with methotrexate is a viable alternative to surgical treatment [56] which was developed in the 1980s. [57] If administered early in the pregnancy, methotrexate terminates the growth of the developing embryo; the developing embryo may then be either resorbed by the woman's body or pass with a menstrual ...
Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
Ectopic pregnancy is treated with methotrexate therapy or surgery. Typically, an intramuscular injection of 50 mg per m^2 of methotrexate is given followed by close monitoring of b-hCG levels 4 and 7 days after injection. B-hCG levels should decrease by at least 15% between those two timepoints. [26]
A rarely used drug combination for uterine pregnancies is methotrexate-misoprostol, which is typically reserved for ectopic pregnancies. [41] Methotrexate is given either orally or intramuscularly, followed by vaginal misoprostol 3–5 days later. [22] The methotrexate combination is available through 63 days.
As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental ...
Misoprostol is regularly used in some Canadian hospitals for labour induction for fetal deaths early in pregnancy, and for termination of pregnancy for fetal anomalies. A low dose is used initially, then doubled for the remaining doses until delivery. In the case of a previous Caesarian section, however, lower doses are used.
Some may go through the same loss when an ectopic pregnancy is terminated. [152] In some, the realisation of the loss can take weeks. Providing family support to those experiencing the loss can be challenging because some find comfort in talking about the miscarriage while others may find the event painful to discuss. The father can have the ...
A cervical pregnancy is an ectopic pregnancy that has implanted in the uterine endocervix. [2] Such a pregnancy typically aborts within the first trimester , however, if it is implanted closer to the uterine cavity – a so-called cervico-isthmic pregnancy – it may continue longer. [ 3 ]