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The subcategorization of Letterer-Siwe disease is a historical eponym. [2] Designating the four subtypes of LCH as separate entities are mostly of historical significance, because they are varied manifestations of the same underlying disease process, and patients also often exhibit symptoms from more than one of the four syndromes. [1]
The disease has gone by several names, including Hand–Schüller–Christian disease, Abt-Letterer-Siwe disease, Hashimoto-Pritzker disease (a very rare self-limiting variant seen at birth) and histiocytosis X, until it was renamed in 1985 by the Histiocyte Society.
[8] [21] Shortly afterwards, Letterer in 1924 and Siwe in 1933 described a fatal condition in children who presented with large livers and spleens, large lymph nodes and bone damage. In 1940, Louis Litchtenstein and Henry L. Jaffe described a self-limiting disease characterised by "isolated bone lesions". [ 9 ]
The plan will also include goals of therapy and patient-specific drug and disease-state monitoring parameters. This should address each item of the differential diagnosis. For patients who have multiple health problems that are addressed in the SOAP note, a plan is developed for each problem and is numbered accordingly based on severity and ...
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Revised Project Plan. The Project Plan gives an overview of the total project, identifies key deliverables, resource requirements, the total cost, and major control points within the project, such as stage boundaries. It is used by the Project Board to measure the progress made and is revised and updated to reflect the latest understanding of ...
The high lipid content in the blood leads to excessive cytoplasm loading of lipids within histiocytes. The subsequent incomplete degradation of these lipids leads to the formation of cytoplasmic lipid pigments.
Aid medical staff in staging the tumor helping to plan the treatment. Give an indication of prognosis. Assist in the evaluation of the results of treatment. Enable facilities around the world to collate information more productively. Since the number of combinations of categories is high, combinations are grouped to stages for better analysis.