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para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. [2] [3] [4] Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, [5] and behaves more like an antidepressant in comparison, [6] though it does have some psychedelic properties.
In addition to its MRA activity, PMMA is a potent monoamine oxidase A (MAO-A) inhibitor. [8] Its IC 50 Tooltip half-maximal inhibitory concentration for MAO-A inhibition has been reported to be 1,700 nM. [8] This is several-fold less potent than the related agents para-methoxyamphetamine (PMA) and 4-methylthioamphetamine (4-MTA). [8]
Substituted amphetamines, or simply amphetamines, are a class of compounds based upon the amphetamine structure; [1] it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.
Current data, which covers between January 1, 2013 and July 1, 2014, shows a dropout rate of 7.5 percent compared with the rate of 22 percent for the opioid addicts not in the program. In the first year, no addict in the new model curriculum died from an overdose.
para-Methoxy ethyl amphetamine (PMEA), is a stimulant drug related to PMA. PMEA reputedly produces similar effects to PMA, but is considerably less potent [1] and seems to have slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death approach those of PMA itself ...
3-Methoxyamphetamine (3-MA), also known as meta-methoxyamphetamine (MMA), is a monoamine releasing agent (MRA) of the amphetamine family. [2] [3] [4] It is a positional isomer of para-methoxyamphetamine (PMA; 4-methoxyamphetamine). [1] [5] 3-MA has similar effects in animal drug discrimination tests to PMA. [2]
Methoxyamphetamine may refer to: 2-Methoxyamphetamine (2-MA) ... 4-Methoxyamphetamine (4-MA) or para-methoxyamphetamine (PMA) See also. Dimethoxyamphetamine;
In most countries, the drug is a controlled substance and its possession and sale are illegal. MDA is rarely sought as a recreational drug compared to other amphetamines ; however, it remains widely used due to it being a primary metabolite, [ 4 ] the product of hepatic N-dealkylation, [ 5 ] of MDMA .