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The dextrorotary enantiomer of methylphenidate, known as dexmethylphenidate, is sold as a generic and under the brand names Focalin and Attenade in both an immediate-release and an extended-release form. There is some evidence that dexmethylphenidate has better bioavailability and a longer duration of action than methylphenidate. [135]
Like amphetamine, methylphenidate (MPH) is a chiral compound which is composed of two isomers: d-threo-methylphenidate (also known as dexmethylphenidate, d-methylphenidate, or d-MPH) and l-threo-methylphenidate (also known as l-methylphenidate or l-MPH).
Ritalin (methylphenidate) – a stimulant used to treat ADHD; ReVia – an opioid antagonist primarily used in the management of alcohol dependence, opioid dependence or other impulse control/addictive behaviors such as habitual self-mutilation; Rexulti (brexpiprazole) – atypical antipsychotic used to treat mood and psychotic disorders
In addition, people using methylphenidate also demonstrated improvements in working memory. This is great news, as people with ADHD may have problems with maintaining focus, impulse control, and ...
Researchers also reported there was no significant psychosis or mania risk increase in study participants receiving methylphenidate, commonly known by one of its brand names, Ritalin.
Amid ongoing ADHD drug shortages, Adderall supplies have improved, but other brand name and generic medications such as Ritalin are still hard to come by, doctors say.
Also of note is that methylphenidate in demethylated form is acidic; a metabolite (and precursor) known as ritalinic acid. [8] This gives the potential to yield a conjugate salt [9] form effectively protonated by a salt nearly chemically duplicate/identical to its own structure; creating a "methylphenidate ritalinate". [10]
A long-acting formulation, Focalin XR, which spans 12 hours is also available and has been shown to be as effective as DL (dextro-, levo-)-TMP (threo-methylphenidate) XR (extended release) (Concerta, Ritalin LA), with flexible dosing and good tolerability. [54] [55] It has also been demonstrated to reduce ADHD symptoms in both children [56] and ...