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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
In 1997, rituximab became the first monoclonal antibody drug for cancer on the market, [7] revolutionizing treatment for B-cell non-Hodgkin lymphoma. [9] Further research by Maloney has continued to develop antibody-based therapeutic strategies for blood cancers. [10] [11]
Adult Atypical Sporadic Burkitt Lymphoma successfully treated with Bendamustine and Rituximab. One combination for stage III/IV relapsed or refractory indolent lymphomas and mantle cell lymphoma (MCL), with or without prior rituximab-containing chemoimmunotherapy treatment, is bendamustine with mitoxantrone and rituximab. [7]
Cancer immunotherapy (immuno-oncotherapy) is the stimulation of the immune system to treat cancer, improving the immune system's natural ability to fight the disease. [1] It is an application of the fundamental research of cancer immunology (immuno-oncology) and a growing subspecialty of oncology.
Cytokine reaction syndrome may also be induced by certain medications, such as the CD20 antibody rituximab and the CD19 CAR T cell tisagenlecleucel. The experimental drug TGN1412—also known as Theralizumab—caused extremely serious symptoms when given to six participants in a Phase I trial. [2]
Results from the 2-year randomized, placebo-controlled, double-blind, multicenter RituxME trial comparing multiple brands of rituximab infusions with placebo in 151 ME/CFS patients concluded that “B-cell depletion using several infusions of rituximab over 12 months was not associated with clinical improvement in patients with ME/CFS,” and ...
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Example of monoclonal antibody (Rituximab) binding to CD20 on B-Cell Surface. I-131 is produced by nuclear fission or through neutron irradiation of Te-130 to convert it to Te-131 which decays to I-131 (produced in the University of Missouri Research Reactor). [35] I-131 is stored in lead-shielding vials.