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Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. [2] [3] Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.
Fel d 1 is the most prominent cat allergen, accounting for 96% of human cat allergies. [4] The remaining cat allergens are Fel d 2–8, [5] with Fel d 4, a major urinary protein found in the saliva of cats, [6] occurring the most in humans among the other seven allergens. All cats produce Fel d 1, including hypoallergenic cats.
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Critiques include that the sample size (only 4 cats) is below statistical significance, was submitted by a Siberian breeder, and as mentioned, one cat was found to have Fel d1 allergen levels of 62.813 μg (roughly 60× higher than any published professional study). [60]
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Fel d1 is a protein primarily found in cat saliva and sebaceous glands. [17] Those with cat allergies may react to direct contact with Sphynx cats. [ 17 ] Even though reports exist that some people with allergies successfully tolerate Sphynx cats, they are fewer than those who have allergic reactions.
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