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Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1] [4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. [5]
Dogs with flea allergy dermatitis often show hair loss and eczematous skin rash on the lower back, upper tail, neck, and down the back of the legs. Cats with flea allergy dermatitis may develop a variety of skin problems, including feline eosinophilic granuloma , miliary dermatitis , or self-inflicted alopecia from excessive grooming.
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.
Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin. [2] Atopic dermatitis is also often called simply eczema but the same term is also used to refer to dermatitis, the larger group of skin conditions. [2] [5] Atopic dermatitis results in itchy, red, swollen, and cracked skin. [2]
Tacrolimus was approved for medical use in the European Union in 2002, for the treatment of moderate to severe atopic dermatitis. [52] In 2007, the indications were expanded to include the prophylaxis of transplant rejection in adult kidney or liver allograft recipients and the treatment of allograft rejection resistant to treatment with other ...
[3] [5] The name is an abbreviation of Veterinary Centers of America, though VCA no longer uses this full name. VCA acquired its first veterinary clinic, West Los Angeles Veterinary Hospital, in 1987. [4] In October 2004, VCA purchased Sound Technologies, [6] a company which supplied digital radiology and ultrasound equipment to veterinary ...
In 2008, it merged with NYC Veterinary Specialists and Cancer Treatment Center in New York City and Veterinary Specialty and Emergency Center in Kansas City, creating BluePearl Specialty and Emergency Pet Hospital. [4] In 2010, Georgia Veterinary Specialists and Michigan Veterinary Specialists also merged with the firm. [5]
Pyotraumatic dermatitis is caused by self-inflicted trauma to the skin, which is incited by pain or irritation, such as infestation with fleas or lice, [4] irritation from clippers, [3] allergic skin diseases, [4] diseases of the anal sacs, [4] inflammation of the ear canal, [4] foreign bodies or irritants within the coat, [4] or pain in muscles or joints. [4]
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