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Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. [ citation needed ] Glucosamine, along with commonly used chondroitin, is not routinely prescribed to treat people who have symptomatic osteoarthritis of the knee, as there is insufficient evidence that this treatment is helpful.
[3] [4] A 2008–2009 review of all known studies of glucosamine supplements for horses, for example, found that almost all studies had failed to meet usual standards and were fatally compromised by basic errors in their execution, including failure to test whether active ingredients were as stated, lack of adequate (or any) control groups or ...
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Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin-4-sulfate: R 1 = H; R 2 = SO 3 H; R 3 = H. Chondroitin-6-sulfate: R 1 = SO 3 H; R 2, R 3 = H.. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
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This led many companies to produce and market resveratrol dietary supplements. However, studies by independent scientists have failed to replicate these results. [ 5 ] [ 6 ] [ 7 ] Moreover, in every experiment to date, resveratrol at several doses has failed to extend the lifespan of lean, genetically normal mice [ 8 ] [ 9 ] [ 10 ] or rats.