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Trimethobenzamide synthesis: Hoffmann La Roche, U.S. patent 2,879,293 (1959). Alkylation of the sodium salt of p -hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2). Reductive amination of the aldehyde in the presence of ammonia gives diamine (3).
3,4,5-Trimethoxybenzaldehyde can be used as an intermediate in the synthesis of some pharmaceutical drugs including trimethoprim, [1] [2] cintriamide, roletamide, trimethoquinol (aka tretoquinol), and trimazosin as well as some psychedelic phenethylamines.
00:28, 25 March 2015: 512 × 95 (29 KB) Nuklear: Sodium methoxide was the base chosen to abstract phenolic hydrogen. 00:14, 25 March 2015: 512 × 99 (29 KB) Nuklear: User created page with UploadWizard
In the patented formation of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose, a reactor containing thionyl chloride (5 ml) and methyl alcohol (100 ml) is stirred at 0–5 °C for 10 to 15 minutes. After this period, 10 g (ratio-wise) of ribose is added to the flask. The flask is then stirred and maintained at its temperature for 8 hours.
2 Synthesis. 3 Derivatives. ... Except where otherwise noted, data are given for materials in their standard state (at 25 °C ... Trimethobenzamide;
The Kulinkovich reaction describes the organic synthesis of substituted cyclopropanols through reaction of esters with dialkyldialkoxytitanium reagents, which are generated in situ from Grignard reagents containing a hydrogen in beta-position and titanium(IV) alkoxides such as titanium isopropoxide. [1]
The Debus–Radziszewski imidazole synthesis is a multi-component reaction used for the synthesis of imidazoles from a 1,2-dicarbonyl, an aldehyde, and ammonia or a primary amine. The method is used commercially to produce several imidazoles. [1] The process is an example of a multicomponent reaction.
Chemical structure of alprazolam, a common triazolobenzodiazepine. Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. . Chemically, they differ from other benzodiazepines by having an additional triazole ring fused to the dia