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There is a small amount of evidence supporting the use of sodium thiosulfate to counteract calciphylaxis, the calcification of blood vessels that may occur in hemodialysis patients with end-stage kidney disease. [15] [16] However, it has been claimed that this treatment may cause severe metabolic acidosis in some patients. [17] [18]
Sodium thiosulfate is used in the treatment of cyanide poisoning. [3] It is on the World Health Organization's List of Essential Medicines. [4] [5] Other uses include topical treatment of ringworm and tinea versicolor, [3] [6] and treating some side effects of hemodialysis [7] and chemotherapy.
It is used as an alternative to chlorine and sodium hypochlorite for disinfection of drinking water and swimming pools. Chloramine-T, or tosylchloramide sodium salt, [(H 3 C)(C 6 H 4)(SO 2)(NHCl)] − Na +. This solid compound is available in tablet or powder form, and used in medical establishments to disinfect surfaces, equipment, and ...
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. [1] It contains sodium thiosulfate and sodium nitrite. [1] It is given by intravenous infusion into a vein. [1] It was approved for medical use in the United States in January 2011. [2]
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
The principal process used to manufacture cyanides is the Andrussow process in which gaseous hydrogen cyanide is produced from methane and ammonia in the presence of oxygen and a platinum catalyst. [21] [22] 2 CH 4 + 2 NH 3 + 3 O 2 → 2 HCN + 6 H 2 O. Sodium cyanide, the precursor to most cyanides, is produced by treating hydrogen cyanide with ...