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They are defined by deficits in cognitive ability that are acquired (as opposed to developmental), typically represent decline, and may have an underlying brain pathology. [1] The DSM-5 defines six key domains of cognitive function: executive function, learning and memory, perceptual-motor function, language, complex attention, and social ...
Urban decay has been found by the Foundation to be "more extreme and therefore more visible" in the north of the United Kingdom. This trend of northern decline has been observed not just in the United Kingdom but also in much of Europe. [17] Some seaside resort towns have also experienced urban decay towards the end of the 20th century.
Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10 and 15 per thousand person-years for all dementias and 5–8 for AD, [236] [237] which means that half of new dementia cases each year are Alzheimer's disease. Advancing age is a primary risk factor for ...
Protein toxicity is one of the key mechanisms of many neurodegenrative diseases. [65] alpha-synuclein: can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Alpha-synuclein is the primary structural component of Lewy ...
The Decay theory is a theory that proposes that memory fades due to the mere passage of time. Information is therefore less available for later retrieval as time passes and memory, as well as memory strength, wears away. [1]
This is an accepted version of this page This is the latest accepted revision, reviewed on 26 January 2025. Long-term brain disorders causing impaired memory, thinking and behavior This article is about the cognitive disorder. For other uses, see Dementia (disambiguation). "Senile" and "Demented" redirect here. For other uses, see Senile (disambiguation) and Demented (disambiguation). Medical ...
Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [1] In neurodegenerative diseases, cells of the central nervous system stop working or die via neurodegeneration. An example of this is Alzheimer's disease. [2]
The central idea of this concept was that in "degenerative" illness, there is a steady decline in mental functioning and social adaptation from one generation to the other. For example, there might be an intergenerational development from nervous character to major depressive disorder, to overt psychotic illness and, finally, to severe and ...