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Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1.
There is currently significant data suggesting that IGFBPs play important roles in addition to their ability to regulate IGFs. IGF-1 and IGFBP-3 are GH dependent, whereas IGFBP-1 is insulin regulated. IGFBP-1 production from the liver is significantly elevated during insulinopenia while serum levels of bioactive IGF-1 is increased by insulin. [10]
This gene is a member of the insulin-like growth factor binding protein family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain.The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms.
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene.IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity.
This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their ...
Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. [5] [6] [7] The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors.
16012 Ensembl n/a ENSMUSG00000023046 UniProt P24592 P47880 RefSeq (mRNA) NM_002178 NM_008344 RefSeq (protein) NP_002169 NP_032370 Location (UCSC) n/a Chr 15: 102.05 – 102.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene. References ^ a b c GRCm38: Ensembl release 89 ...
16008 Ensembl ENSG00000115457 ENSMUSG00000039323 UniProt P18065 P47877 RefSeq (mRNA) NM_001313990 NM_001313992 NM_001313993 NM_000597 NM_008342 NM_001310659 RefSeq (protein) NP_000588 NP_001300919 NP_001300921 NP_001300922 NP_001297588 NP_032368 Location (UCSC) Chr 2: 216.63 – 216.66 Mb Chr 1: 72.86 – 72.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Insulin-like growth ...