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The endocannabinoid system, broadly speaking, includes: Endocannabinoids, which are the physiological ligands, or connecting substances, for the cannabinoid receptors.The main endocannabinoids are anandamide (N-arachidonoylethanolamide) and 2-AG (2-arachidonoylglycerol), which are in the same class of chemical compounds, called N-acylethanolamines (NAEs).
The Endocannabinoid System (ECS) regulates many functions of the human body. The ECS plays an important role in multiple aspects of neural functions, including the control of movement and motor coordination, learning and memory, emotion and motivation, addictive-like behavior and pain modulation, among others.
Anandamide, the first discovered endocannabinoid, engages with the body's endocannabinoid system by binding to the same cannabinoid receptors that THC found in cannabis acts on. Anandamide can be found within tissues in a wide range of animals. [1] [2] It has also been found in plants, such as the cacao tree. [3]
Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound. [10] Similar responses are produced when introduced in alternative methods, only in a more concentrated form than what is naturally occurring.
Clinical endocannabinoid deficiency (CECD) is a medical theory that proposes that a deficiency of endocannabinoids is the underlying pathophysiology of migraines, fibromyalgia, and irritable bowel syndrome. [1] [2] The deficiency may sometimes start in the womb as a result of maternal obesity. [3]
Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. [5] And discovered, by determination and characterization in 1988, [6] and cloned in 1990 for the first time.
2166 14073 Ensembl ENSG00000117480 ENSMUSG00000034171 UniProt O00519 O08914 RefSeq (mRNA) NM_001441 NM_010173 RefSeq (protein) NP_001432 NP_034303 Location (UCSC) Chr 1: 46.39 – 46.41 Mb Chr 4: 115.82 – 115.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fatty-acid amide hydrolase 1 (FAAH) is a member of the serine hydrolase family of enzymes. It was first shown to break down ...
The catalytic efficiency (i.e., the ratio between maximal velocity and Michaelis–Menten constant) of the AEA membrane transporter (AMT) is almost doubled compared with control cells, demonstrate that, among the proteins of the “endocannabinoid system,” only CB1 and AMT critically depend on membrane cholesterol content, an observation that ...