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In general, treatment with cephalosporins results in induction of AmpC beta-lactamase. [2] Treatment with an aminoglycoside or carbapenem is usually indicated. Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity. They have a structure that renders them highly resistant to beta-lactamases.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
The message reads, in part, "If your pet is drooling or foaming at the mouth look for these lady bugs. They cause ulcers on the tongue and mouth and have a very painful bite."
A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. [2]
Flucloxacillin is a narrow-spectrum antibiotic belonging to the penicillin group of antibiotics. [8] [27] It works by breaking down the bacterial cell wall. [27] Like other β-lactam antibiotics, flucloxacillin acts by inhibiting the synthesis of bacterial cell walls.