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Dietary recommendations for cancer prevention typically include weight management and eating a healthy diet, consisting mainly of "vegetables, fruit, whole grains and fish, and a reduced intake of red meat, animal fat, and refined sugar." [1] A healthy dietary pattern may lower cancer risk by 10–20%. [12]
Cancer prevention is the practice of taking active measures to decrease the incidence of cancer and mortality. [ 1 ] [ 2 ] The practice of prevention depends on both individual efforts to improve lifestyle and seek preventive screening , and socioeconomic or public policy related to cancer prevention. [ 3 ]
Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective, also known as the Expert Report, was an expert report published by the World Cancer Research Fund global network in 2007. It reviewed all the evidence about the links between cancer and diet, physical activity and body fat and contains 10 recommendations for ...
Rather than oxidizing glucose for ATP production, glucose in cancer cells tends to be used for anabolic processes, such as ribose production, protein glycosylation and serine synthesis. This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs.
Modulating the pyrimidine metabolism pharmacologically has therapeutical uses, and could implement in cancer treatment. [10] Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid arthritis and psoriatic arthritis, as well as in multiple sclerosis.
Glycosylation also plays a role in cell-to-cell adhesion (a mechanism employed by cells of the immune system) via sugar-binding proteins called lectins, which recognize specific carbohydrate moieties. [2] Glycosylation is an important parameter in the optimization of many glycoprotein-based drugs such as monoclonal antibodies. [6]
Preventive nutrition has been known about for a long time. The philosopher Hippocrates (460-377 BC) believed that nutrition had a significant impact on maintaining health and that the best way to prevent diseases was to "let food be your medicine and medicine be your food.” [4] Meyer-Abich (2005) also believed that nutrition was foundational to a healthy life. [7]
Animal-derived foods that are high in fat and protein are generally AGE-rich and are prone to further AGE formation during cooking. [3] However, only low molecular weight AGEs are absorbed through diet, and vegetarians have been found to have higher concentrations of overall AGEs compared to non-vegetarians. [ 4 ]