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Intermediate mesoderm or intermediate mesenchyme is a narrow section of the mesoderm (one of the three primary germ layers) located between the paraxial mesoderm and the lateral plate of the developing embryo. [1] The intermediate mesoderm develops into vital parts of the urogenital system (kidneys, gonads and respective tracts).
Mesenchyme (/ ˈ m ɛ s ə n k aɪ m ˈ m iː z ən-/ [1]) is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. [2] [3] The interactions between mesenchyme and epithelium help to form nearly every organ in the developing embryo. [4]
The intermediate mesoderm gives rise to the urogenital tract and consists of cells that migrate from the middle region of the primitive line. Other cells migrate through the caudal part of the primitive line and form the lateral mesoderm, and those cells migrating by the most caudal part contribute to the extraembryonic mesoderm.
The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
The intermediate mesoderm connects the paraxial mesoderm with the lateral plate mesoderm, and differentiates into urogenital structures. [12] In upper thoracic and cervical regions, this forms the nephrotomes. In caudal regions, it forms the nephrogenic cord. It also helps to develop the excretory units of the urinary system and the gonads. [4]
The seven previous multi-format Women's Ashes have seen the following results (home side listed first): Test win was worth six points until 2015, when it was reduced to four. 2013: England 12-4 ...
In the development of the human embryo, the intraembryonic coelom (or somatic coelom) is a portion of the conceptus forming in the mesoderm during the third week of development. [1]
These experiments reveal that the limb mesenchyme contains the necessary information concerning limb identity, but the AER is needed to stimulate the mesenchyme to live up to its destiny (of becoming an arm, leg, etc.) When the AER is removed, limb development halts. If an FGF-bead is added in the AER's place, normal limb development proceeds.