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Gluconeogenesis (GNG) is a metabolic pathway that results in the biosynthesis of glucose from certain non-carbohydrate carbon substrates. It is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms. [1]
Under one percent of ingested fructose is directly converted to plasma triglyceride. [1] 29% - 54% of fructose is converted in liver to glucose, and about a quarter of fructose is converted to lactate. 15% - 18% is converted to glycogen. [2] Glucose and lactate are then used normally as energy to fuel cells all over the body. [1]
Only plants possess the enzymes to convert acetyl-CoA into oxaloacetate from which malate can be formed to ultimately be converted to glucose. [1] However, acetyl-CoA can be converted to acetoacetate, which can decarboxylate to acetone (either spontaneously, or catalyzed by acetoacetate decarboxylase).
Glucose-6-phosphate can then progress through glycolysis. [1] Glycolysis only requires the input of one molecule of ATP when the glucose originates in glycogen. [1] Alternatively, glucose-6-phosphate can be converted back into glucose in the liver and the kidneys, allowing it to raise blood glucose levels if necessary. [2]
When needed, the liver releases glucose into the blood by performing glycogenolysis, the breakdown of glycogen into glucose. [48] The liver is also responsible for gluconeogenesis, which is the synthesis of glucose from certain amino acids, lactate, or glycerol. Adipose and liver cells produce glycerol by breakdown of fat, which the liver uses ...
Liver cell glycogen can be converted to glucose and returned to the blood when insulin is low or absent; muscle cell glycogen is not returned to the blood because of a lack of enzymes. In fat cells, glucose is used to power reactions that synthesize some fat types and have other purposes. Glycogen is the body's "glucose energy storage ...
The 100 g (0.2 lb) or so of glycogen stored in the liver is depleted within one day of starvation. [11] Thereafter the glucose that is released into the blood by the liver for general use by the body tissues, has to be synthesized from the glucogenic amino acids and a few other gluconeogenic substrates, which do not include fatty acids. [12]
Lipid metabolism also occurs in plants, though the processes differ in some ways when compared to animals. [8] The second step after the hydrolysis is the absorption of the fatty acids into the epithelial cells of the intestinal wall. [6] In the epithelial cells, fatty acids are packaged and transported to the rest of the body. [9]