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Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [4] Central to the physiologic maintenance of GFR is the differential basal tone of the afferent (input) and efferent (output) arterioles (see diagram).
The estimated glomerular filtration rate (eGFR) is a measure of kidney function. [6] Adding a race adjustment to kidney algorithms results in higher eGFR values in people identified as black. [7] [8] [9] Reasons for this vary, but it is thought to partially stem from the notion that Black persons are more muscular. [8]
EGFR may refer to: Epidermal growth factor receptor (EGFR), a transmembrane receptor protein in humans Estimated glomerular filtration rate (eGFR), a measure of renal function
[53] [54] Those who should be screened include: those with hypertension or history of cardiovascular disease, those with diabetes or marked obesity, those aged > 60 years, subjects with African American ancestry, those with a history of kidney disease in the past, and subjects who have relatives who had kidney disease requiring dialysis.
Mutations that lead to EGFR overexpression (known as upregulation or amplification) have been associated with a number of cancers, including adenocarcinoma of the lung (40% of cases), anal cancers, [18] glioblastoma (50%) and epithelian tumors of the head and neck (80–100%). [19]
The other major component of the ECF is the intravascular fluid of the circulatory system called blood plasma. The remaining small percentage of ECF includes the transcellular fluid. These constituents are often called "fluid compartments". The volume of extracellular fluid in a young adult male of 70 kg, is 20% of body weight – about ...
Rather they refer to what percentage of the total weight is milk fat. For example, one cup of milk weighs about 225 grams. Of that weight, 2% milk holds 5 grams of fat and whole milk contains 8 grams.
Severe renal impairment (estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m 2) [75] Known hypersensitivity to metformin [ 75 ] Acute or chronic metabolic acidosis , including diabetic ketoacidosis (from uncontrolled diabetes), [ 75 ] with or without coma [ 76 ]