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A 100 mg Rimadyl tablet approximately 19 mm (0.75 in) wide by 8.6 mm (0.34 in) thick, as sold in the USA. Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in animals. [1]
carprofen – COX-2 selective NSAID used to relieve pain and inflammation in dogs and cats; cefpodoxime – antibiotic; cephalexin – antibiotic, particularly useful for susceptible Staphylococcus infections; ciprofloxacin – antibiotic of quinolone group
Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). [3] Like other NSAIDs, its effects are caused by inhibition of cyclooxygenase (COX) enzymes. [7] At the doses used to treat dogs, deracoxib causes greater inhibition of COX-2 than of COX-1, [3] but at doses twice those recommended for use in dogs, deracoxib significantly inhibits COX-1 as well.
The use of tepoxalin was more effective than the NSAID (nonsteroidal anti-flammatory drug), carprofen when administered in canines. As a result, the usage of carprofen was replaced with tepoxalin in 1998. [6] Tepoxalin can only be administered to dogs that weigh 3 pounds (1.4 kg) or larger at a dose of 10–20 mg/kg at a daily schedule. [7]
The FDA link that supposedly lists Carprofen's dangers is dead, too, as are others. The hyperlink about Carprofen's human use also details toxicological studies in animals. "In dogs dose levels of 2 and 7 mg carprofen/kg" daily for 1 year "were well tolerated with no gross autopsy or histological changes." [1]
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