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Xenon Xe 129 hyperpolarized, sold under the brand name Xenoview, is a hyperpolarized contrast agent indicated for use with magnetic resonance imaging (MRI) for evaluation of lung ventilation, and approved for people aged twelve years of age and older. [4] [5] It was approved for medical use in the US in December 2022. [6]
Compared with solar xenon, Earth's atmospheric Xe is enriched in heavy isotopes by 3 to 4% per atomic mass unit (amu). [18] However, the total abundance of xenon gas is depleted by one order of magnitude relative to other noble gases. [15] The elemental depletion while relative enrichment in heavy isotopes is called the "Xenon paradox".
The hyperpolarization method called spin-exchange optical pumping (SEOP) is being used to hyperpolarize noble gases such as Xenon-129 and Helium-3. When an inhaled hyperpolarized gas like 3He or 129Xe is imaged, there is a higher magnetization density of NMR-active molecules in the lung compared to traditional 1H imaging, which improves the MRI ...
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In order to obtain images of the subject's lung tissue, the polarized xenon gas is inhaled through a tube connected to a mouthpiece. The subject is instructed to take a deep breath and exhale fully twice before inhaling the gas. The typical scan uses a mixture of 200-1000 ml of 129Xe and a buffer gas such as helium or nitrogen.