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The laminin B domain (also known as domain IV) is an extracellular module of unknown function. It is found in a number of different proteins that include, heparan sulphate proteoglycan from basement membrane, a laminin-like protein from Caenorhabditis elegans and laminin. Laminin IV domain is not found in short laminin chains (alpha4 or beta3).
16776 Ensembl ENSG00000130702 ENSMUSG00000015647 UniProt O15230 Q61001 RefSeq (mRNA) NM_005560 NM_001081171 RefSeq (protein) NP_005551 NP_001074640 Location (UCSC) Chr 20: 62.31 – 62.37 Mb Chr 2: 179.82 – 179.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene. Function Components of the extracellular ...
Confocal microscopic analysis of a dermal fibroblast in primary culture from a control (a and b) and the subject with HGPS (c and d). Labelling was performed with anti-lamin A/C antibodies. Note the presence of irregularly shaped nuclear envelopes in many of the subject's fibroblasts
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The nuclear lamina consists of two components, lamins and nuclear lamin-associated membrane proteins. The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B 1, B 2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle.
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4001 16906 Ensembl ENSG00000113368 ENSMUSG00000024590 UniProt P20700 P14733 RefSeq (mRNA) NM_001198557 NM_005573 NM_010721 RefSeq (protein) NP_001185486 NP_005564 NP_034851 Location (UCSC) Chr 5: 126.78 – 126.84 Mb Chr 18: 56.84 – 56.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of ...
16773 Ensembl ENSG00000196569 ENSMUSG00000019899 UniProt P24043 Q60675 RefSeq (mRNA) NM_000426 NM_001079823 NM_008481 RefSeq (protein) NP_000417 NP_001073291 NP_032507 Location (UCSC) Chr 6: 128.88 – 129.52 Mb Chr 10: 26.86 – 27.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene. Function Laminin, an ...