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Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption. [4] Calcitonin has a greater effect in young children than in adults, and plays a smaller role in bone remodeling than PTH. [4]
PTHrP acts similarly to parathyroid hormone in that it binds to the parathyroid hormone 1 receptors on the kidneys and bones and causes an increased tubular reabsorption of calcium and activation of osteoclast activity, respectively. [22] Osteoclasts are a type of bone cell which cause bone resorption, releasing calcium into the bloodstream.
The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, [5] particularly with respect to bone formation and metabolism. [6] [7] [8]
Osteoclasts are regulated by several hormones, including parathyroid hormone (PTH) from the parathyroid gland, calcitonin from the thyroid gland, and growth factor interleukin 6 (IL-6). This last hormone, IL-6, is one of the factors in the disease osteoporosis. Osteoporosis occurs when there is an imbalance between the bone resorption ...
Calcitonin lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts. Osteoblasts do not have calcitonin receptors and are therefore not directly affected by calcitonin levels. However, since bone resorption and bone formation are coupled processes, eventually calcitonin's inhibition of osteoclastic activity leads to ...
Yuta Okkotsu (Japanese: 乙骨 憂太, Hepburn: Okkotsu Yūta) is the protagonist of Gege Akutami's manga Jujutsu Kaisen 0.He is a teenager who is surrounded and helped by the Cursed Spirit of Rika Orimoto, his childhood friend who died six years before the story and is cursed because both of them promised to get married when they grow up.
Jujutsu Kaisen (呪術廻戦, rgh. "Sorcery Battle") [a] is a Japanese manga series written and illustrated by Gege Akutami.It was serialized in Shueisha's shōnen manga magazine Weekly Shōnen Jump from March 2018 to September 2024, with its chapters collected in 30 tankōbon volumes.
Jujutsu Kaisen: Cursed Clash [a] is a fighting game co-developed by Byking and Gemdrops, [1] and published by Bandai Namco Entertainment.Based on the 2020 anime adaptation of Gege Akutami's manga series, Jujutsu Kaisen, the game was released on February 1, 2024, in Japan for the Nintendo Switch, PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S, [2] which was followed by a ...