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In 2005 the landscape of the mammalian genome was described as numerous 'foci' of transcription that are separated by long stretches of intergenic space. [9] While some long ncRNAs are located within the intergenic stretches, the majority are overlapping sense and antisense transcripts that often include protein-coding genes, [23] giving rise to a complex hierarchy of overlapping isoforms. [24]
How NORAD works with PUM proteins to contribute to genomic instability. [1]Noncoding RNA Activated by DNA Damage (NORAD) is a long non-coding RNA that responds to DNA damage and plays a significant role in preserving stability (keeping it accurate and unchanged) of genetic information within cells. [2]
The transcriptome includes the transcripts of protein-coding genes (mRNA plus introns) as well as the transcripts of non-coding genes (functional RNAs plus introns). Ribosomal RNA/rRNA: Usually the most abundant RNA in the transcriptome. Long non-coding RNA/lncRNA: Non-coding RNA transcripts that are more than 200 nucleotides long. Members of ...
The roles of non-coding RNAs: Ribonucleoproteins are shown in red, non-coding RNAs in blue. A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene.
Identification, expression, evolution and function of long non-coding RNAs (LncRNAs), small RNAs and circular RNAs from deep-sequencing data [3] LNCipedia: A comprehensive compendium of human long non-coding RNAs. [4] [5] lncRNAdb: The Reference Database For Functional Long Noncoding RNAs. [6] LncRNAWiki
It is important to distinguish the 5' and 3' UTRs from other non-protein-coding RNA. Within the coding sequence of pre-mRNA, there can be found sections of RNA that will not be included in the protein product. These sections of RNA are called introns. The RNA that results from RNA splicing is a sequence of exons. The reason why introns are not ...
Circular ANRIL (cANRIL) is the circular form of ANRIL, a long non-coding RNA (ncRNA). Expression of cANRIL is correlated with risk for atherosclerosis, a disease in which the arteries become hard. It has been proposed that cANRIL can modify INK4/ARF expression, which, in turn, increases risk for atherosclerosis. [40]
For example, long non-coding RNA can directly interact with transcriptional repressors and activators, attenuating or modifying their function. [15] This type of regulation can occur in different ways: the RNA transcript can directly bind to the transcription factor as a co-regulator; also, the RNA can regulate and modify the ability of co ...