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The Dutch sprinter Foekje Dillema was expelled from the 1950 national team after she refused a mandatory sex test in July 1950; later investigations revealed a Y-chromosome in her body cells, and the analysis showed that she probably was a 46,XX/46,XY mosaic female.
In 1992, the majority of the sports federations under the IOC stopped performing any type of gender testing. Judo was one of the five federations that continued testing, and the IOC itself replaced the chromosome testing with a DNA-based test. This test was carried out on all female athletes in 1996.
The Y chromosome is one of two sex chromosomes in therian mammals and other organisms. Along with the X chromosome, it is part of the XY sex-determination system, in which the Y is the sex-determining chromosome because the presence of the Y chromosome causes offspring produced in sexual reproduction to be of male sex.
Sex-determination system. Some chromosomal sex determination systems in animals. A sex-determination system is a biological system that determines the development of sexual characteristics in an organism. [1] Most organisms that create their offspring using sexual reproduction have two common sexes and a few less common intersex variations.
The XY sex-determination system is a sex-determination system present in many mammals, including humans, some insects (Drosophila), some snakes, some fish (guppies), and some plants (Ginkgo tree). In this system, the sex of an individual usually is determined by a pair of sex chromosomes. Typically, females have two of the same kind of sex ...
46,XX/46,XY chimeric or mosaic is associated with a wide spectrum of different physical presentations, with cases ranging from having a completely normal male or female phenotype [7] [8] [9] to some cases having ovotesticular syndrome. Due to this variation, genetic testing is the only way to reliably make a diagnosis. [11] [12] [13] [6]