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  2. Angiotensin-converting enzyme - Wikipedia

    en.wikipedia.org/wiki/Angiotensin-converting_enzyme

    The angiotensin converting enzyme gene has more than 160 polymorphisms described as of 2018. [24] Studies have shown that different genotypes of angiotensin converting enzyme can lead to varying influence on athletic performance. [25] [26] However, these data should be interpreted with caution due to the relatively small size of the ...

  3. Cardiovascular agents - Wikipedia

    en.wikipedia.org/wiki/Cardiovascular_agents

    Antihypertensive agents are classified according to their mechanism of actions. The most common classes prescribed are diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and ...

  4. Angiotensin (1-7) - Wikipedia

    en.wikipedia.org/wiki/Angiotensin_(1-7)

    The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) [7] and thimet oligopeptidase (TOP) [8] enzymes. Also, Ang II can be hydrolyzed into Ang (1-7) through the actions of angiotensin-converting enzyme 2 (ACE2).

  5. Angiotensin - Wikipedia

    en.wikipedia.org/wiki/Angiotensin

    Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys. An oligopeptide, angiotensin is a hormone and a ...

  6. Renin–angiotensin system - Wikipedia

    en.wikipedia.org/wiki/Renin–angiotensin_system

    ACE inhibitors of angiotensin-converting enzyme inhibitors are often used to reduce the formation of the more potent angiotensin II. Captopril is an example of an ACE inhibitor. ACE cleaves a number of other peptides, and in this capacity is an important regulator of the kinin–kallikrein system , as such blocking ACE can lead to side effects.

  7. Discovery and development of ACE inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of captopril, the first ACE inhibitor. When the adverse effects of captopril became apparent new derivates were designed.

  8. Angiotensin-converting enzyme 2 - Wikipedia

    en.wikipedia.org/.../Angiotensin-converting_enzyme_2

    Membrane bound angiotensin-converting enzyme 2 (mACE2) is a zinc-containing metalloenzyme located on the surface of intestinal enterocytes, renal tubular cells and other cells. [6] [17] mACE2 protein contains an N-terminal peptidase M2 domain and a C-terminal collectrin renal amino acid transporter domain. [17]

  9. Discovery and development of angiotensin receptor blockers

    en.wikipedia.org/wiki/Discovery_and_development...

    Blood pressure and fluid and electrolyte homeostasis is regulated by the renin–angiotensin–aldosterone system. [1] Renin, an enzyme released from the kidneys, converts the inactive plasma protein angiotensinogen into angiotensin I (Ang I). Then Ang I is converted to Ang II with angiotensin converting enzyme (ACE), see figure 2. Ang II in ...