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The long elimination half-life of dutasteride should be taken into consideration in the event of an overdose of the medication. [50] Dutasteride has been used in clinical studies at doses of up to 40 mg/day for a week (80 times the therapeutic dosage) and 5 mg/day for 6 months (10 times the therapeutic dosage) with no significant safety ...
Dutasteride was approved for the treatment of BPH in 2001 and was subsequently approved for pattern hair loss in South Korea in 2009 and in Japan in 2015. [44] [45] The patent protection on finasteride and dutasteride has expired and both drugs are available as generic medications. [46] [47]
Polonium in the body has a biological half-life of about 30 to 50 days. Caesium in the body has a biological half-life of about one to four months. Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years.
Hair today, gone tomorrow can make any man rush to their healthcare provider for a solution to regain their once-full head of hair. But with so many treatment options out there, how’s a guy ...
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
The 5-alpha reductase blockers like finasteride reduce DHT levels and slow down, stop or reverse the effects of male pattern baldness. They can also encourage hair regrowth and increase hair count.
Dutasteride (Avodart) was the second steroidal 5α-reductase approved after finasteride. It is a competitive inhibitor of all three 5α-reductase isoenzymes [ 4 ] and it inhibits types 1 and 2 better than finasteride, leading to it causing further reduction in DHT, with >90% reduced DHT levels following 1 year of oral administration.
Learn how muscle memory works, how long it takes to develop, and why it’s crucial for fitness. Plus, tips to train smarter and build strength and muscle faster.