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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system.The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. [5]
In terms of total mass, myelin comprises approximately 40% water; the dry mass comprises between 60% and 75% lipid and between 15% and 25% protein. Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte ...
In enzymology, a [myelin basic protein]-arginine N-methyltransferase (EC 2.1.1.126) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + [myelin basic protein]-arginine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-arginine
Myelin basic protein is the antigen in the myelin sheaths of the neurons that stimulates an autoimmune reaction in people with MS, so the peptide may work as a decoy for the attacking immune cells. Glatiramer acetate was originally discovered at the Weizmann Institute of Science. It is on the World Health Organization's List of Essential ...
Using a novel protocol, myelin basic protein (MBP), a marker for oligodendrocyte differentiation and myelination in the CNS, was detectable as early as day 63 (9 weeks) and myelinated axons were observed by day 105 (15 weeks), effectively halving the duration of the protocol. [17] [18]
The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the efficiency of axonal impulse conduction. [ 2 ] In humans, point mutations in PLP are the cause of Pelizaeus–Merzbacher disease (PMD), a neurologic disorder of myelin metabolism.
18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. Myelin protein P2 is a ...
She found that p27 regulates the differentiation of oligodendrocytes by modulating transcription of the gene for myelin basic protein. [12] Casaccia found in 2002 that the delicate balance of proapoptotic and antiapoptotic molecules determine the propensity for cell death. [ 13 ]