Ads
related to: sod2 enzyme
Search results
Results From The WOW.Com Content Network
The SOD2 enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling. [11] Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans.
SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists of two units), whereas the others are tetramers (four subunits). SOD1 and SOD3 contain copper and zinc, whereas SOD2, the mitochondrial enzyme, has manganese in its reactive centre.
SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.
Superoxide dismutase (SOD) mimetics are synthetic compounds that mimic the native superoxide dismutase enzyme. [1] SOD mimetics effectively convert the superoxide anion (O − 2), a reactive oxygen species, into hydrogen peroxide, which is further converted into water by catalase. [2]
Ribbon drawing of the subunit 3D structure of Cu,Zn superoxide dismutase. Irwin Fridovich (August 2, 1929 – November 2, 2019) [1] was an American biochemist who, together with his graduate student Joe M. McCord, discovered the enzymatic activity of copper-zinc superoxide dismutase (SOD), [2] [3] —to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct ...
Also contrary to this theory, deletion of mitochondrial SOD2 can extend lifespan in Caenorhabditis elegans. [51] In mice, the story is somewhat similar. Deleting antioxidant enzymes, in general, yields shorter lifespan, although overexpression studies have not (with some exceptions) consistently extended lifespan. [52]
20657 Ensembl ENSG00000109610 ENSMUSG00000072941 UniProt P08294 O09164 RefSeq (mRNA) NM_003102 NM_011435 RefSeq (protein) NP_003093 NP_035565 Location (UCSC) Chr 4: 24.79 – 24.8 Mb Chr 5: 52.52 – 52.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of ...
In enzymology, a sulochrin oxidase [(+)-bisdechlorogeodin-forming] (EC 1.21.3.4) is an enzyme that catalyzes the chemical reaction. 2 sulochrin + O 2 2 (+)-bisdechlorogeodin + 2 H 2 O. Thus, the two substrates of this enzyme are sulochrin and O 2, whereas its two products are (+)-bisdechlorogeodin and H 2 O.