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Leukodystrophy is characterized by specific symptoms, including decreased motor function, muscle rigidity, and eventual degeneration of sight and hearing. While the disease is fatal, the age of onset is a key factor, as infants have a typical life expectancy of 2–8 years, while adults typically live more than a decade after onset.
These symptoms first start out with dysfunctions of the autonomic nervous system which result in symptoms such as abnormal functioning of both the bladder and bowel, recurrent blood pressure drops whenever patients stand up, and male erectile dysfunction. [8] [9] [10] Rarely, anhidrosis might also occur alongside these symptoms. [9] [8] [11] [10]
The adult form commonly begins after age 16 often with an onset in the 4th or 5th decade of life and presents as a psychiatric disorder or progressive dementia. Adult-onset MLD usually progresses more slowly than the late infantile and juvenile forms, with a protracted course of a decade or more.
White matter degeneration is associated with and makes differential diagnoses out of other adult onset leukodystrophies such as metachromatic leukodystrophy (MLD), Krabbe disease (globoid cell leukodystrophy), and X-linked adrenoleukodystrophy (X-ADL). [2]
Onset of the juvenile form presents between 2 and 12 years of age. [6] Duration of this form is in most cases about six years. The adult form occurs after 12 years. [6] In younger patients, seizures, megalencephaly, developmental delay, and spasticity are usually present. Neonatal onset is also reported. [21] Onset in adults is least frequent.
The signs of adult-onset allergies aren’t always obvious, and they can easily be confused with other conditions. “One of the major symptoms many people overlook is poor quality sleep. If ...
Onset usually occurs in childhood, however some adult cases have been found. Generally, physicians look for the symptoms in children. Symptoms include cerebellar ataxia, spasticity, optic atrophy, epilepsy, [1] loss of motor functions, irritability, vomiting, coma, [2] and even fever has been tied to VWM. [3]
Visceral fat is the type of fat that surrounds your internal organs in your abdomen. It can be particularly worrisome because it's housed in places where fat shouldn't be stored in excess. While ...