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The example used for the following description is Human adenovirus E, a mastadenovirus with a 36 Kbp genome containing 38 protein-coding genes. [2] While the precise number and identity of genes varies among adenoviruses, the basic principles of genome organization and the functions of most of the genes described in this article are shared ...
Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. [ 1 ] [ 9 ] Typical symptoms range from those of a common cold , such as nasal congestion , rhinitis , and cough , to difficulty breathing as in pneumonia . [ 9 ]
A replication-deficient chimpanzee adenovirus vaccine vector (ChAdOx1) is used by the Oxford–AstraZeneca COVID-19 vaccine that has been approved for use. [52] [53] The Janssen COVID-19 vaccine uses modified recombinant adenovirus type-26 (Ad26). [54] Recombinant adenovirus type-5 (Ad5) are being used by Ad5-nCoV, [55] ImmunityBio and UQ-CSL V451.
In August 2022, 9 children in a U.S. case series of hepatitis of unknown cause [7] and 27 of 30 children in a U.K. case series with hepatitis of unknown cause who underwent molecular testing [8] tested positive for human adenovirus type 41 in a sample. It was unclear whether human adenovirus 41 was the cause, however. [citation needed]
Human adenovirus 36 (HAdV-36) or Ad-36 or Adv36 is one of 52 types of adenoviruses known to infect humans. AD-36, first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis, [ 1 ] has long been recognized as a cause of respiratory and eye infections in humans. [ 2 ]
Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections.According to the United States Centers for Disease Control and Prevention (CDC), as of September 2007, outbreaks have been identified in four states in the U.S., with ten identified deaths since May 2006.
The VA (viral associated) RNA is a type of non-coding RNA found in adenovirus. [1] [2] It plays a role in regulating translation. [3] There are two copies of this RNA called VAI or VA RNAI and VAII or VA RNAII. These two VA RNA genes are distinct genes in the adenovirus genome. VA RNAI is the major species with VA RNAII expressed at a lower level.
In March 2023, a series of Nature papers detected high titres of adeno-associated virus 2 (AAV2), alongside adenovirus and herpesvirus, in samples from a wave of childhood hepatitis. [6] One paper suggested that AAV2 co-infection may contribute to more serious liver disease than infection with only adeno- or herpesviruses and that the causal ...