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Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. [1] The condition is caused by excessive intravascular hemolysis , in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma . [ 2 ]
Hemoglobinuria can be caused by hemolytic anaemia, blood transfusions, extensive burns, the bite of the recluse spider (Loxosceles), infections and strenuous exercise. The urine test strip test for blood is based on hemoglobin's pseudo peroxidase activity in catalysing a reaction between hydrogen peroxide and the chromogen tetramethylbenzidine ...
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
Hemoglobinuria, if unaccompanied by a high quantity of RBCs, can signify intravascular hemolysis (destruction of red blood cells inside the body). [144] Myoglobinuria occurs in rhabdomyolysis and other conditions that cause breakdown of muscle tissue.
The ominous eye of Hurricane Milton is visible in stunning detail from outer space in a timeplapse video released Tuesday by NASA.. From 275 miles above Earth, the powerful storm can be seen ...
Image credits: Photoglob Zürich "The product name Kodachrome resurfaced in the 1930s with a three-color chromogenic process, a variant that we still use today," Osterman continues.
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