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  2. Ceftazidime - Wikipedia

    en.wikipedia.org/wiki/Ceftazidime

    Ceftazidime, sold under the brand name Fortaz among others, is a third-generation cephalosporin antibiotic useful for the treatment of a number of bacterial infections. [1] [5] Specifically it is used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, Pseudomonas aeruginosa infection, and vibrio infection. [1]

  3. Beta-lactamase - Wikipedia

    en.wikipedia.org/wiki/Beta-lactamase

    The amino acid substitutions responsible for the extended-spectrum beta lactamase (ESBL) phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to β ...

  4. Kluyvera - Wikipedia

    en.wikipedia.org/wiki/Kluyvera

    In 2010, a gene bla CTX-M-15 responsible for coding CTX-M-15 extended-spectrum β-lactamase (ESBL) jumped from its chromosome to its plasmid, which was then shared among several bacteria. ESBL confers resistance to pathogenic bacterial strains. This caused the development of antibiotic resistance in almost all known pathogenic bacteria at that ...

  5. List of antibiotics - Wikipedia

    en.wikipedia.org/wiki/List_of_antibiotics

    Antibiotics that cover Pseudomonas aeruginosa: Certain cephalosporins, cephalosporin-beta-lactamase-inhibitor combinations, and new siderophore cephalosporins.

  6. Piperacillin - Wikipedia

    en.wikipedia.org/wiki/Piperacillin

    Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. [1] The chemical structure of piperacillin and other ureidopenicillins incorporates a polar side chain that enhances penetration into Gram-negative bacteria and reduces susceptibility to cleavage by Gram-negative beta lactamase enzymes.

  7. β-Lactam antibiotic - Wikipedia

    en.wikipedia.org/wiki/Β-Lactam_antibiotic

    β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.

  8. Cephalosporin - Wikipedia

    en.wikipedia.org/wiki/Cephalosporin

    / ˌ s ɛ f ə l ə ˈ s p ɔːr ɪ n, ˌ k ɛ-,-l oʊ-/ [1] [2]) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as Cephalosporium. [3] Together with cephamycins, they constitute a subgroup of β-lactam antibiotics called cephems. Cephalosporins were discovered in 1945, and first ...

  9. Carbapenem-resistant enterobacteriaceae - Wikipedia

    en.wikipedia.org/wiki/Carbapenem-resistant_enter...

    One study from Japan found that 6.4% of healthy adults carried ESBL (mostly cefotaximase)-producing strains compared to 58.4% in Thailand, where antibiotics are available over the counter and without prescription. An Egyptian research group found that 63.3% of healthy adults were colonized. [9]