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Yvonne Margaret Balding [2] [3] (née Barr; [2] 11 March 1932 – 13 February 2016) [3] was an Irish virologist who co-discovered the Epstein–Barr virus (EBV), [4] [5] which, because it identified a virus as a cause of cancer in humans, has been called "one of the 20th century's most significant scientific discoveries."
In 1964, using electron microscopy, Anthony Epstein and his research assistant Bert Achong discovered viral particles in EB cells, resulting in the seminal paper published in 1964, "Virus particles in cultured lymphoblasts from Burkitt's lymphoma" by Epstein, Achong and Barr. This was the first demonstration of viral particles in a human tumour.
The Epstein–Barr virus (EBV) is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus and is also called human herpesvirus 4 (HHV-4). [2] Epstein–Barr virus (EBV) is the first identified oncogenic virus, or a virus that can cause cancer. EBV ...
James Corson Niederman (November 27, 1924 – March 2, 2024) was an American epidemiologist whose research identified the Epstein–Barr virus as the cause of infectious mononucleosis in a study published in 1968. [1] [2]
Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). [ 2 ] [ 3 ] Most people are infected by the virus as children, when the disease produces few or no symptoms. [ 2 ]
Achong, Anthony Epstein and Yvonne Barr discovered the first example of a human cancer-causing virus. [4] They published the discovery of the Epstein–Barr virus (EBV) in The Lancet on 28 March 1964. Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt lymphoma samples by electron microscopy. [5 ...
There are several forms of Epstein–Barr virus (EBV) infection. These include asymptomatic infections, the primary infection, infectious mononucleosis, and the progression of asymptomatic or primary infections to: 1) any one of various Epstein–Barr virus-associated lymphoproliferative diseases such as chronic active EBV infection, EBV+ hemophagocytic lymphohistiocytosis, Burkitt's lymphoma ...
The virus was later shown to be a previously unrecognised herpes virus, which is now called Epstein–Barr virus. [55] Surprisingly, Epstein–Barr virus is a very common but relatively mild infection of Europeans. Why it can cause such a devastating illness in Africans is not fully understood, but reduced immunity to virus caused by malaria ...