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There is no level of BNP that perfectly separates patients with and without heart failure. [14]In screening for congenital heart disease in pediatric patients, an NT-proBNP cut-off value of 91 pg/mL could differentiate an acyanotic heart disease (ACNHD) patient from a healthy patient with a sensitivity of 84% and specificity of 42%. [15]
BNP and NT-proBNP are also typically increased in patients with left ventricular dysfunction, with or without symptoms (BNP accurately reflects current ventricular status, as its half-life is 20 minutes, as opposed to 1–2 hours for NT-proBNP). [22] A preoperative BNP can be predictive of a risk of an acute cardiac event during vascular surgery.
N-terminal pro-BNP (NT-proBNP) is the favored biomarker for the diagnosis of heart failure, according to guidelines published 2018 by NICE in the UK. [3] Brain natriuretic peptide 32 (BNP) is another biomarker commonly tested for heart failure. [74] [6] [75] An elevated NT-proBNP or BNP is a specific test indicative of heart failure ...
B-type natriuretic peptide (BNP) and its pro hormone NT-proBNP are especially useful in diagnosing heart failure, as their levels in the blood increase along with the severity of the condition. [3] Rapid testing of BNP and NT-proBNP can also help distinguish between shortness of breath due to heart and lung-related causes.
[84] [85] [86] Measurement of circulating cardiac biomarkers, like N‐terminal‐proBNP (NT‐proBNP) [87] [88] and troponin I (TnI) may be used in cats to strengthen the suspicion of cardiac disease. [89] There is a Point-of-care test for feline NT-proBNP available which can be used at the veterinary clinic when echocardiography is not ...
NT-proBNP. Interpretation Age Cutoff; Congestive heart failure likely < 75 years > 125 pg/mL [62] > 75 years > 450pg/mL [62] Lipids Test Patient type Lower limit ...
Cardiac markers are used for the diagnosis and risk stratification of patients with chest pain and suspected acute coronary syndrome and for management and prognosis in patients with diseases like acute heart failure. Most of the early markers identified were enzymes, and as a result, the term "cardiac enzymes" is sometimes used. However, not ...
This also applies to patients with elevated NT-proBNP levels and patients with atrial enlargement in cardiac ultrasound. Other causes: Arterial dissections, infection-related vasculopathies (esp. Varicella zoster virus), thrombophilia, cancer-related thrombosis, migraine, Fabry disease and other genetic, autoimmune or rheumatic causes.