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This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form a multiprotein complex called the NLRP3 inflammasome. The pro-caspase-1 is brought into close proximity with other pro-caspase molecule in order to dimerise and undergo auto-proteolytic cleavage.
Setting a value for any of the cell or organelle attributes will make its diagram visible; Any number and combination of diagram attributes may be set; When multiple diagrams are activated, the title is suppressed {
The most notable components of the cell that are targets of cell damage are the DNA and the cell membrane.. DNA damage: In human cells, both normal metabolic activities and environmental factors such as ultraviolet light and other radiations can cause DNA damage, resulting in as many as one million individual molecular lesions per cell per day.
Diagram of both the TC-NER and GG-NER pathways. The two pathways differ only in initial DNA damage recognition. [1] Nucleotide excision repair is a DNA repair mechanism. [2] DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens.
One of several templates for styling individual table cells with standard contents and colors. Template parameters [Edit template data] This template prefers inline formatting of parameters. Parameter Description Type Status text 1 text to be displayed instead of the default; if this doesn't work put the text after the template, possibly with a vertical bar | in between Default (template ...
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By definition, stem cells possess two properties: (1) they can self-renew, which means that they can divide indefinitely while remaining in an undifferentiated state; and (2) they are pluripotent or multipotent, which means that they can differentiate to form specialized cell types.