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Feline diabetes mellitus is a chronic disease in cats whereby either insufficient insulin response or insulin resistance leads to persistently high blood glucose concentrations. Diabetes affects up to 1 in 230 cats , [ 1 ] and may be becoming increasingly common.
Bexacat is the first sodium-glucose cotransporter 2 (SGLT2) inhibitor new animal drug approved by the US Food and Drug Administration (FDA) in any animal species. [2] It was approved for medical use in the United States in December 2022. [2] [10] Bexacat is sponsored by Increvet Inc., based in Boston, Massachusetts. [2]
methimazole – used in treatment of hyperthyroidism; methocarbamol - muscle relaxant used to reduce muscle spasms associated with inflammation, injury, intervertebral disc disease, and certain toxicities; metoclopramide – potent antiemetic, secondarily as a prokinetic; metronidazole – antibiotic against anaerobic bacteria
As a medication, insulin is any pharmaceutical preparation of the protein hormone insulin that is used to treat high blood glucose. [6] Such conditions include type 1 diabetes, type 2 diabetes, gestational diabetes, and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. [6]
Shop safe cat flea treatments and medicines approved by vets, including topical gels, collars, and oral tablets from Revolution, Advantage, Frontline, and more.
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):