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Some iron preparations can trigger anaphylaxis in patients with certain allergies. Serious hypersensitivity including anaphylactic reactions have been reported with the use of high molecular weight iron dextran for intravenous iron infusions. [12] The use of high molecular weight iron dextran has now been abandoned.
Intravenous iron is administered directly to the bloodstream, in a form of iron carbohydrate complexes, such as iron dextran and iron sucrose. The complex is composed of a polynuclear Fe3+ hydroxide core with a surrounding carbohydrate shell. [ 4 ]
One formulation of parenteral iron is iron dextran which covers the old high molecular weight (brand name Dexferrum) and the much safer low molecular iron dextrans (brand names including Cosmofer and Infed). [59] Iron sucrose has an occurrence of allergic reactions of less than 1 in 1000. [60]
Dextran has indirect applications in nanoparticles as a coating. Iron oxide nanoparticles coated with dextran can be loaded with the microRNA miR-29a to selectively target breast cancer cells and down-regulate anti-apoptotic genes leading to successful breast cancer treatment. [6]
The researchers found iron infusions reduced the risk of hospitalisation due to heart failure and dying from a heart related cause by 18% compared to usual care.
Last year, Medicare reached agreements to lower prices on the 10 costliest drugs, including Eliquis, a blood thinner; Imbruvica, a blood cancer treatment; and NovoLog, a diabetes medication.
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