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Coumarin (/ ˈ k uː m ər ɪ n /) or 2H-chromen-2-one is an aromatic organic chemical compound with formula C 9 H 6 O 2.Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by an unsaturated lactone ring −(CH)=(CH)−(C=O)−O−, forming a second six-membered heterocycle that shares two carbons with the benzene ring.
Coumarin derivates Retards absorption of drug [3] St John's wort Tipton's weed, Klamath weed Hypericum perforatum: Antidepressants, [15] [16] warfarin, protease inhibitors for HIV, birth control, some asthma drugs, and many other medications [16]
Coumatetralyl is commonly used with grains and other cereals as a rodent poison in conjunction with a tracking powder to monitor feeding activity in a particular area. . Tracking powder also clings to fur, which allows more poison to be ingested from g
Coumarin is known to cause liver and kidney damage in high concentrations and metabolic effect in humans with CYP2A6 polymorphism. [73] [74] Based on this assessment, the European Union set a guideline for maximum coumarin content in foodstuffs of 50 mg per kg of dough in seasonal foods, and 15 mg per kg in everyday baked foods. [75]
Because of this, people taking anticoagulant medications such as aspirin, coumarin, and warfarin may want to consult with their doctor about any dietary restrictions, including fish." This article ...
It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.
This is due to the presence of the chemical compound coumarin in the bean. Coumarin has been linked to liver failure, but only at unreasonably high concentrations. Amazon
For human consumption, ... an isoflavone coumarin derivative, is the only coumestan in foods. ... FDA has accepted SBIFs as safe for use as the sole source of nutrition.