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2. Limbic-predominant age-related TDP-43 encephalopathy

   en.wikipedia.org/wiki/Limbic-predominant_age...

   Insets show TDP-43 positive neuronal cytoplasmic inclusions (Inset A--in dentate granule cells) and wispy non-tapering cellular processes stained for TDP-43 protein (Inset B--in CA1). LATE is a term that describes a prevalent medical condition with impaired memory and thinking in advanced age, often culminating in the dementia clinical syndrome ...

3. Memory loss isn’t always Alzheimer’s: Experts warn of common ...

   www.aol.com/news/memory-loss-isn-t-always...

   As Alzheimer’s disease is the most common form of dementia — affecting an estimated 6.7 million Americans ... "LATE is defined by changes in the TDP-43 protein in brain tissue and frequently ...

4. New criteria defined for memory loss condition often mistaken ...

   www.aol.com/criteria-defined-memory-loss...

   Previous studies have found build-ups of TDP-43 in the limbic system of autopsied brain tissue of older adults, which is referred to as limbic-predominant age-related TDP-43 encephalopathy (LATE-NC).

5. Frontotemporal lobar degeneration - Wikipedia

   en.wikipedia.org/wiki/Frontotemporal_lobar...

   Frontotemporal lobar degeneration; Neuropathologic analysis of brain tissue from FTLD-TDP patients. Ubiquitin immunohistochemistry in cases of familial FTLD-TDP demonstrates staining of (a) neurites and neuronal cytoplasmic inclusions in the superficial cerebral neocortex, (b) neuronal cytoplasmic inclusions in hippocampal dentate granule cells, and (c) neuronal intranuclear inclusions in the ...

6. TAR DNA-binding protein 43 - Wikipedia

   en.wikipedia.org/wiki/TAR_DNA-binding_protein_43

   TDP-43 is 414 amino acid residues long. It consists of four domains: an N-terminal domain spanning residues 1–76 (NTD) with a well-defined fold that has been shown to form a dimer or oligomer; [6] [7] two highly conserved folded RNA recognition motifs spanning residues 106–176 (RRM1) and 191–259 (RRM2), respectively, required to bind target RNA and DNA; [8] an unstructured C-terminal ...

7. Eli Lilly Beefs Up Neuro Pipeline With Addition Of ... - AOL

   www.aol.com/eli-lilly-beefs-neuro-pipeline...

   A defining feature of both sporadic and familial disease is the cytoplasmic mis-localization of TAR DNA Binding Protein-43 (TDP-43). TDP-43 pathology is implicated in 90% of ALS cases and ...