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Wuchereria bancrofti is a filarial (arthropod-borne) nematode (roundworm) that is the major cause of lymphatic filariasis. It is one of the three parasitic worms, together with Brugia malayi and B. timori, that infect the lymphatic system to cause lymphatic filariasis. These filarial worms are spread by a variety of mosquito vector species.
Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. [2] [3] Usually acquired in childhood, it is a leading cause of permanent disability worldwide, impacting over a hundred million people and manifesting itself in a variety of severe clinical pathologies [6] [7] While most cases have no symptoms, some people develop a syndrome called elephantiasis, which ...
Chronic filarial disease develops gradually over the years. In most patients the lymphatic dilation does not present any physical symptoms. However, inflammatory responses to dying adult worms often lead to chronic lymphedema in the affected regions which then progresses to elephantiasis. W. bancrofti often causes hydrocele and scrotal ...
Elephantiasis tropica (known as lymphatic filariasis), caused by a number of parasitic worms, particularly Wuchereria bancrofti. More than 120 million people, mostly in Africa and Southeast Asia, are affected. [3] Nonfilarial elephantiasis (or podoconiosis), an immune disease affecting the lymph vessels [citation needed] Leishmaniasis [2]
Three species of filarial roundworms, all from the Onchocercidae family, cause human lymphatic filariasis: Wuchereria bancrofti, Brugia malayi, and Brugia timori. [1] Tropical pulmonary eosinophilia is a rare syndrome characterised by pulmonary interstitial infiltrates and marked peripheral eosinophilia. [2]
Extrapolating from research done with Wuchereria bancrofti, another nematode that causes filariasis, Wolbachia may aid in embryogenesis of the worm, be responsible for potent inflammatory responses from macrophages and filarial disease, and be linked to the onset of lymphedema and blindness sometimes associated with B. malayi infections.
Diethylcarbamazine is indicated for the treatment of people with certain filarial diseases, including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; loiasis and tropical pulmonary eosinophilia. [11]
Wuchereria bancrofti [7] Three other medically important parasitic species are: Loa loa causes Loa loa filariasis also known as Calabar swelling; Mansonella streptocerca, which causes streptocerciasis, an itchy condition that creates depigmented skin lesions sometimes mistaken for the first signs of leprosy.