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Wuchereria bancrofti is a filarial (arthropod-borne) nematode (roundworm) that is the major cause of lymphatic filariasis. It is one of the three parasitic worms, together with Brugia malayi and B. timori, that infect the lymphatic system to cause lymphatic filariasis. These filarial worms are spread by a variety of mosquito vector species.
Wuchereria bancrofti (Wb) belonging to the family Onchocercidae, accounts for more than 90% of the filarial infections worldwide. It completes its life cycle across two hosts, humans being the definitive host while the mosquitoes act as the intermediate host.
Various filarial diseases specific to humans are candidates for elimination by such means as breaking the cycle of infection. To eliminate the vectors is not really practical, but if the human population were sufficiently cleared of parasites by treatment with filaricides then one year without any human reservoirs of infection should suffice to ...
The microfilaria (plural microfilariae, sometimes abbreviated mf) is an early stage in the life cycle of certain parasitic nematodes in the family Onchocercidae. [1] In these species, the adults live in a tissue or the circulatory system of vertebrates (the "definitive hosts"). They release microfilariae into the bloodstream of the vertebrate host.
He made important researches in leprosy and became well known through his studies in filaria disease; he was the discoverer of the mature parasite Filaria bancrofti and was one of the first to suggest it was borne by mosquitoes. Bancroft was a leading scientist of his period in Queensland.
The inability of the parasite to complete its life cycle within humans means that transmission can easily be contained by adequate preparation of meat from intermediate hosts. This is especially useful because of the difficulty and lack of feasibility inherent in eliminating all intermediate hosts of gnathostomiasis.
According to the Filarial Genome Project being done by The Special Programme for Research and Training in Tropical Diseases, the Brugia malayi MIF gene is expressed in all life-cycle stages of the parasite, and results suggest that B. malayi MIF may interact with the human immune system during the course of infection by altering the function of ...
Compared to infections with other filarial parasites such as Wuchereria bancrofti, Brugia malayi, and Loa loa, Mansonella infections are relatively mild. However, the pathogenicity of M. perstans infection has been recently reconsidered in various studies. [ 3 ]