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Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. [ 8 ] [ 9 ] [ 10 ] For acne, it is applied to the skin as a cream, gel or ointment. [ 10 ]
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Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [6]
Effective agents for specific areas include corticosteroids, tretinoin, and hydroquinone. [6] These agents are not allowed in cosmetics in Europe due to concerns about side effects. [6] Attempts to whiten large areas of skin may also be carried out by certain cultures. [6] This may be done for reasons of appearance, politics, or economics. [6]