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A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues. [ 1 ] modRNA is used to induce the production of a desired protein in certain cells.
Lentiviral delivery of designed shRNAs and the mechanism of RNA interference in mammalian cells. RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression.
Ribosomally synthesized and post-translationally modified peptides (RiPPs), also known as ribosomal natural products, are a diverse class of natural products of ribosomal origin. [1] Consisting of more than 20 sub-classes, RiPPs are produced by a variety of organisms , including prokaryotes , eukaryotes , and archaea , and they possess a wide ...
To achieve the self-propagating nature of gene drives, this repair template contains at least the endonuclease sequence. Because the template must be used to repair a double-strand break at the cutting site, its sides are homologous to the sequences that are adjacent to the cutting site in the host genome. By targeting the gene drive to a gene ...
The modified gene therapy strategy of antisense IGF-I RNA (NIH n˚ 1602) [168] using antisense / triple helix anti-IGF-I approach was registered in 2002, by Wiley gene therapy clinical trial - n˚ 635 and 636.
Opinion - Trump was his worst self at the debate, while Harris cleared a low bar. Bernard Goldberg, Opinion Contributor. September 12, 2024 at 11:30 AM.
Unmodified aptamers can treat coagulation disorders. The problem of clearance and nuclease digestion is diminished when they are applied to the eye, where there is a lower concentration of nuclease and the rate of clearance is lower. [29] Rapid clearance from serum can also be useful in some applications, such as in vivo diagnostic imaging.
Opinion - In a self-censoring world, telling uncomfortable truths is resistance. Svante Myrick, opinion contributor. January 13, 2025 at 9:00 AM. Ann Telnaes is my new hero.