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In 1984–1986, John G. Kelton and colleagues at McMaster University Medical School developed the laboratory tests that could be used to confirm or exclude heparin-induced thrombocytopenia. [4] [19] Treatment was initially limited to aspirin and warfarin, but the 1990s saw the introduction of a number of agents that could provide ...
One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000/μL. [5] Thrombocytopenia can be contrasted with the conditions associated with an abnormally high level of platelets in the blood – thrombocythemia (when the cause is unknown), and thrombocytosis (when the cause is known). [6] [7]
Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes. [5] anemia: hemoglobin < 13.5 g/dL (male) or < 12 g/dL (female). leukopenia: total white cell count < 4.0 x 10 9 /L. Decrease in all types of white blood cells (revealed by doing a differential count). thrombocytopenia: platelet count < 150×10 9 /L.
Thrombotic thrombocytopenic purpura (TTP) initially presents with a range of symptoms that may include severe thrombocytopenia (platelet count usually < 30,000/mm³), microangiopathic hemolytic anemia (evidenced by schistocytes in the blood smear), and various clinical signs such as petechiae, purpura, neurologic symptoms, myocardial ischemia ...
Bleeding time may be affected by platelet function, certain vascular disorders and von Willebrand Disease—not by other coagulation factors such as haemophilia.Diseases that may cause prolonged bleeding time include thrombocytopenia, disseminated intravascular coagulation (DIC), Bernard-Soulier disease, and Glanzmann's thrombasthenia.
3 Treatment. 4 See also. 5 References. ... Diagnosis is done by the help of symptoms and only blood count abnormality is thrombocytopenia. [citation needed] Treatment
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