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Mutator methods can be compared to assignment operator overloading but they typically appear at different levels of the object hierarchy. Mutator methods may also be used in non-object-oriented environments. In this case, a reference to the variable to be modified is passed to the mutator, along with the new value. In this scenario, the ...
The post-replicative Mismatch Repair System (MMRS) of Escherichia coli involves MutS (Mutator S), MutL and MutH proteins, and acts to correct point mutations or small insertion/deletion loops produced during DNA replication. [1] MutS and MutL are involved in preventing recombination between partially homologous DNA sequences.
Mutator methods are used to modify the data of an object. Manager methods are used to initialize and destroy objects of a class, e.g. constructors and destructors. These methods provide an abstraction layer that facilitates encapsulation and modularity .
Mutator method, an object method that changes the state of the object; Mutator, the application program which mutates the object dependency graph in garbage collection; Mutator genotype, a genotype that exhibits high rates of mutation; Mutator, the central shaft in some scraped surface heat exchangers
Its endonuclease function is taken up by MutL homologs, which have some specialized 5'-3' exonuclease activity. The strand bias for removing mismatches from the newly synthesized daughter strand in eukaryotes may be provided by the free 3' ends of Okazaki fragments in the new strand created during replication.
The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Defects in hMSH6 are associated with atypical hereditary nonpolyposis colorectal cancer not fulfilling the Amsterdam criteria for HNPCC. hMSH6 mutations have also been linked to endometrial cancer and the development of endometrial ...
Recognizing those mismatches and repairing them is important for cells because failure to do so results in microsatellite instability] and an elevated spontaneous mutation rate (mutator phenotype). Among 20 cancers evaluated, microsatellite instable colon cancer (mismatch repair deficient) had the second highest frequency of mutations (after ...
A substitution of one amino acid for another can impair protein function and tertiary structure, however its effects may be minimal or tolerated depending on how closely the properties of the amino acids involved in the swap correlate. [11] The premature insertion of a stop codon, a nonsense mutation, can alter the primary structure of a ...