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Mycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. [1] [2] First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid.
Robert Koch, a Prussian physician, discovered the cause of tuberculosis. Villemin's experiments had confirmed the contagious nature of the disease and had forced the medical community to accept that tuberculosis was indeed an infectious disease, transmitted by some etiological agent of unknown origin.
At the time, it was widely believed that tuberculosis was an inherited disease. However, Koch was convinced that the disease was caused by a bacterium and was infectious. In 1882, he published his findings on tuberculosis, in which he reported the causative agent of the disease to be the slow-growing Mycobacterium tuberculosis. [25]
Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, [7] is a contagious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. [1] Tuberculosis generally affects the lungs , but it can also affect other parts of the body. [ 1 ]
Robert Hermann Koch (11 December 1843 – 27 May 1910) was a German physician who developed Koch's postulates. [1]Koch's postulates (/ k ɒ x / KOKH) [2] are four criteria designed to establish a causal relationship between a microbe and a disease.
Tuberculosis sputum is the main agent for the conveyance of the virus of tuberculosis from man to man. Indiscriminate spitting should therefore be suppressed. Overcrowding and defective ventilation, damp and insanitary dwellings of the working classes diminish the chances of curing consumption, and are predisposing causes of the disease.
Koch had transformed bacteriology by introducing the technique of pure culture, whereby he established the microbial cause of the disease anthrax (1876), had introduced both staining and solid culture plates to bacteriology (1881), had identified the microbial cause of tuberculosis (1882), had incidentally popularized Koch's postulates for ...
Koch first discovered mycobacterium tuberculosis as the cause of tuberculosis in 1892 but the strains he studied were not preserved and it is unclear how related H37Rv may be to those strains. H37Rv has continued to be the strain of tuberculosis most used in laboratories, and was the first to have its complete genome published in 1998. [5]