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Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant. [9] [1] [10] [11] It was once common in prescription and over-the-counter cough and cold preparations.
Dexatrim formula has changed considerably over the years. In prior formulations, Dexatrim contained the decongestant phenylpropanolamine (PPA) and the amphetamine-like compound ephedra. [13] A 2000 study by Yale University School of Medicine showed an increased risk of hemorrhagic stroke with taking PPA. [14]
[9] [27] However, another study found that phentermine was a weak human serotonin 5-HT 2C receptor partial agonist (EC 50 Tooltip half-maximal effective concentration = 1,394 nM, V max = 66%). [27] In accordance with its lack of serotonin release and serotonin 5-HT 2B receptor agonism, phentermine appears to show no risk of primary pulmonary ...
Norephedrine (phenylpropanolamine) is an active metabolite of ephedrine formed via N-demethylation. [ 6 ] [ 10 ] About 8 to 20% of an oral dose of ephedrine is demethylated into norephedrine, about 4 to 13% is oxidatively deaminated into benzoic acid , and a small fraction is converted into 1,2-dihydroxy-1-phenylpropane.
Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea.
Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in people age two and older. [3] [7] [4]Dravet syndrome is a life-threatening, rare and chronic form of epilepsy. [7]
L-Norpseudoephedrine, or (−)-norpseudoephedrine, is a psychostimulant drug of the amphetamine family. It is one of the four optical isomers of phenylpropanolamine, the other three being cathine ((+)-norpseudoephedrine), (−)-norephedrine, and (+)-norephedrine; as well as one of the two enantiomers of norpseudoephedrine (the other being cathine). [1]
1-Amino-2-propanol Betaxolol Metoprolol Nadolol Pindolol Propranolol Timolol. Propanolamines are a class of chemical compounds, many of which are pharmaceutical drugs. They are amino alcohols that are derivatives of 1-amino-2-propanol.