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Most people who have taken too much of a calcium channel blocker, especially diltiazem, get slow heart rate and low blood pressure (vasodilatory shock). [1] This can progress to the heart stopping altogether. [2] CCBs of the dihydropyridine group, as well as flunarizine, predominantly cause reflex tachycardia as a reaction to the low blood ...
Although rare, [36] amlodipine overdose toxicity can result in widening of blood vessels, severe low blood pressure, and fast heart rate. [37] Toxicity is generally managed with fluid replacement [ 38 ] monitoring ECG results, vital signs, respiratory system function, glucose levels, kidney function, electrolyte levels, and urine output.
Slowing down the conduction of electrical activity within the heart, by blocking the calcium channel during the plateau phase of the action potential of the heart (see: cardiac action potential), results in a negative chronotropic effect, or a lowering of heart rate. This can increase the potential for heart block.
The most efficient way to lower your heart rate is through breathing, says Dr. Wang. “Deep exhalations can decrease your heart rate. Breathing in through the nose for the count of 4, holding it ...
Class IV agents are slow non-dihydropyridine calcium channel blockers. They decrease conduction through the AV node, and shorten phase two (the plateau) of the cardiac action potential. They thus reduce the contractility of the heart, so may be inappropriate in heart failure.
So, your heart health has more to do with the conditioning of the heart muscle than the actual heart rate itself, Dr. Weinberg explains. How long does it take to lower your resting heart rate?